Everything You Need To Know About Biphasic Electrical Stimulation

May 24, 2023by William Bozeman

Electrical stimulation, or e-stim, is a form of therapy that uses electrical signals to trigger muscle contractions, which can provide short-term to long-term pain relief based on the intensity of the e-stim treatment. Medical professionals have used e-stim for decades, and it is now common practice to help treat various issues and conditions, from minor muscle injuries to chronic pain. 

However, you should note that there are different e-stim treatment solutions. For example, biphasic e-stim treatment is commonly used by physical therapists to help treat a range of issues.

What Is Biphasic Electrical Stimulation?

Biphasic electrical stimulation is a type of waveform used in e-stim therapy. It is one of the most commonly used waveforms in e-stim therapy, and it is often used to help strengthen muscles, re-educate muscles, decrease swelling, and increase circulation.

Biphasic electrical stimulation works by sending two different pulses (or phases) at two different intensities that alternate (which is why it’s sometimes known as alternating current therapy as well). This type of e-stim treatment differs from the traditional direct current used in other e-stim solutions, as it does not necessarily use a continuous stream of electricity to stimulate the affected area. Instead, it uses two different pulses, one positive and one negative, that are delivered in quick succession to generate a therapeutic effect.

Types Of Biphasic Electrical Stimulation

When it comes to biphasic e-stim treatments, there are two main types. These include symmetrical biphasic waveforms and asymmetrical biphasic waveforms. The following is a breakdown of both types:

Symmetrical Biphasic Waveforms

Symmetrical biphasic waveforms use identical phases that cancel each other out, thereby producing a zero-net charge. As a result, they are less likely to cause a skin reaction. Symmetrical biphasic waveforms are also less fatiguing than polyphasic waveforms because they require less energy from the device to deliver a therapeutic effect, making them more comfortable for the patient to use. 

Symmetrical biphasic waveforms are used by variable muscle stimulator (VMS) units. Because symmetrical biphasic waveforms help generate greater torque with muscle contractions, VMS units are commonly used to help stimulate and strengthen large muscle groups.

Asymmetrical Biphasic Waveforms

Asymmetrical biphasic waveforms consist of non-identical phases that can be either balanced with no net charge or unbalanced, yielding a net charge. Asymmetrical biphasic waveforms are commonly used with transcutaneous electrical nerve stimulation (TENS) units, which tend to be more helpful for targeting and strengthening small muscle groups.

How It Works

Biphasic electrical stimulation works by sending alternating pulses that cause a change in the electrical potential between two points. This produces an electrochemical reaction that causes muscles to contract and relax, depending on the intensity of the electrical stimulus. 

The change in electrical potential can help reduce pain and inflammation, in addition to re-educating muscles. This improved muscle response can then be used to help strengthen the affected muscle group and improve overall physical function. It can also improve circulation and reduce swelling.

Conditions And Symptoms Treated By Biphasic Electrical Stimulation

Because biphasic electrical stimulation can help both small and large muscle groups to contract and relax to reduce inflammation, swelling, and pain, as well as to increase circulation, e-stim units (such as TENS and VMS) are commonly used to treat a variety of conditions and symptoms, including:


Biphasic electrical stimulation can reduce inflammation and improve circulation, which can help reduce acute and chronic pain by relaxing tight muscles, decreasing spasms, and improving blood flow to the area. This increased circulation helps promote healing and reduces pain signals send to the the brain, resulting in a decrease in pain.

Muscular and Disc Syndromes

Biphasic electrical stimulation can help reduce muscular tension and spasms and improve muscle tone in the affected areas. This improved muscle tone can help reduce back, neck, and shoulder pain caused by muscular or disc syndromes, such as herniated discs, pinched nerves, and sciatica. Additionally, improving muscle strength and range of motion can help reduce the likelihood of future pain and injuries.


Arthritis is inflammation of the joints and surrounding tissues that can cause pain, stiffness, swelling, and decreased range of motion. Biphasic electrical stimulation can help improve circulation to the affected area, thereby reducing inflammation and swelling. Additionally, improved muscle contractions and relaxation can help increase the affected joint’s range of motion, reducing stiffness and soreness.


Neuropathies refer to a type of nerve damage that can cause numbness, tingling, and pain in the affected area. Biphasic electrical stimulation can relieve these symptoms by helping to reduce inflammation and muscle spasms. Additionally, improved circulation can help the nerve cells to regenerate, reducing pain and restoring sensation in the affected area.

Biphasic electrical stimulation should be avoided in patients with certain cardiac conditions, including those with pacemakers, and any condition that warrants avoiding electrical stimulation, such as open wounds or infections. Additionally, pregnant women and people with epilepsy should not use biphasic electrical stimulation. Finally, patients should always consult with their medical provider before using any type of electrical stimulation to ensure safety and effectiveness.

Other Electrical Stimulation Treatments You Should Consider

TENS is a frequently used type of biphasic electrical stimulation, but there is another treatment option available: electroanalgesia. The problem with TENS units is that despite using biphasic waveforms, the pulse rate is low. At most, a TENS unit can only deliver around 400 pulses a second. At-home TENS units have an even lower pulse rate, topping out at 250. Because the pulse rate is so low, the pain neurons being targeted won’t be as affected and can even re-polarize, which means that any relief you might experience from TENS treatment will likely be temporary.

At Neuragenex, we use electroanalgesia therapy instead. Electroanalgesia can provide long-term relief because it delivers electrical currents at up to 10,000 pulses per second. A frequency of at least 8300 pulses per second is required to target the neurons’ pain fibers effectively.

Get The Right E-Stim Therapy To Ease Your Pain Safely

E-stim therapy is a safe and effective way to help relieve pain from many conditions. However, it’s essential to understand how e-stim devices work and that not all forms of e-stim are the same. If you’re suffering from chronic pain, you’ll want to choose a type of e-stim therapy that provides long-term relief. As such, consider electroanalgesia as part of our Neuragenex protocol to manage chronic pain.

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William Bozeman

by William Bozeman

William is a healthcare executive, innovator, entrepreneur, inventor, and writer with a wide range of experience in the medical field. William has multiple degrees in a wide range of subjects that give depth to his capability as an entrepreneur and capacity to operate as an innovative healthcare executive. William has an associate degree in electrical technology, two undergraduate degrees in biotechnology and archaeology, an MBA, and attended medical school in Alabama. William took a leave of absence from medical school to open his first biotech lab and serve as the chief science officer, writer, and innovator. William has founded and launched multiple biotech ventures while serving in a range of positions in that field as chief executive officer, chief science officer, chief medical officer, founder, and innovator. William has brought multiple biologic products to market for clinical use applications and written many treatment protocols for application of use and helped pioneer the use of regenerative medicine in the medical field. William's research-based protocols paved the way for widescale procedure use application in the medical field. Many physicians and medical providers still use his protocols in their practice today and have shared their success and techniques with hundreds of physicians and providers. William was one of the first entrepreneurs to actively help integrate regenerative medicine into mainstream healthcare and coached hundreds of physicians and providers across the nation in the use of regenerative medicine.

William has founded and launched a range of new medical businesses and served as an executive in multiple companies in the healthcare field:

  • Multiple biotech and biologic product production labs with robust national and international distribution
  • Multiple high complex clinical toxicology and PCR labs
  • A nationwide allergy and immunotherapy medical service organization with dozens of locations
  • Founded and opened multiple medical practices and medical service programs specializing chronic pain management without medications, surgery, or invasive procedures.


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Copyright 2023 Neuragenex. All rights reserved.

Copyright 2023 Neuragenex. All rights reserved.